Scientific Research on Silicon
Clinical studies for Mesoporosil® & Highly Bioavailable Silicon
Mesoporosil® Studies
Studies specifically evaluating Mesoporosil® or formulations containing Mesoporosil®.
Mohta et al., 2025 — CosmoDerma
Method: 84-day human interventional study in women aged 40–66 assessing daily Mesoporosil® supplementation.
Outcome: Reported improvements in skin firmness, hydration, and elasticity with good tolerability and no adverse events.
Link: https://cosmoderma.org/article.asp?issn=2710-2586;year=2025;volume=5;issue=1;spage=33
Arpino et al., 2023 — PharmaNutrition
Method: Comparative human study in patients with minor vertebral fractures receiving standard bracing with or without a Mesoporosil®-containing supplement (with vitamins D3 and K2).
Outcome: Faster resolution of bone edema and earlier orthosis removal in the supplemented group compared to control.
Link: https://www.sciencedirect.com/journal/pharma-nutrition
Motta et al., 2024 — PharmaNutrition
Method: In-vitro study using human osteoblast-like MG-63 cells exposed to Mesoporosil®, including glucocorticoid-stress conditions.
Outcome: Increased collagen type I synthesis and osteocalcin expression; improved osteoblast viability under stress conditions.
Link: https://www.sciencedirect.com/journal/pharma-nutrition
Mesoporosil® Ex-Vivo Bioavailability Study (Ussing chamber)
Method: Ex-vivo intestinal transport model assessing silicon passage across intestinal tissue.
Outcome: Demonstrated intestinal transport of silicon from Mesoporosil® in a physiologically relevant form.
Link: Not publicly published (supplier technical dossier)
Mesoporosil® Pre-Clinical Evaluation (2021)
Method: Pre-clinical assessment referenced in supplier documentation (model not publicly disclosed).
Outcome: Listed as supporting bioavailability and biological activity.
Link: Not publicly published (supplier technical dossier)
Silicon & Bone Health — Key Studies
Independent research investigating dietary or bioavailable silicon in relation to bone biology and skeletal health.
Jugdaohsingh et al., 2004 — American Journal of Clinical Nutrition
Method: Observational analysis from the Framingham Offspring Study assessing dietary silicon intake.
Outcome: Higher silicon intake associated with greater hip bone mineral density in men and premenopausal women.
Link: https://academic.oup.com/ajcn/article/80/4/1075/4690392
Spector et al., 2008 — BMC Musculoskeletal Disorders
Method: Randomised, placebo-controlled trial of choline-stabilised orthosilicic acid in osteopenic women receiving calcium and vitamin D.
Outcome: Changes observed in bone formation markers compared with placebo.
Link: https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-9-85
Macdonald et al., 2012 — British Journal of Nutrition
Method: Population study examining silicon intake relative to bone density and oestrogen status.
Outcome: Associations between silicon intake and BMD differed by hormonal status.
Link: https://www.cambridge.org/core/journals/british-journal-of-nutrition
Reffitt et al., 2003 — Bone
Method: In-vitro study exposing human osteoblast-like cells to orthosilicic acid at physiological concentrations.
Outcome: Stimulation of collagen type I synthesis and osteoblast differentiation.
Link: https://www.sciencedirect.com/science/article/pii/S8756328203000839
Magnusson & Ransjö, 2024 — Journal of Trace Elements in Medicine and Biology
Method: In-vitro osteoclast differentiation model assessing effects of orthosilicic acid.
Outcome: Inhibition of osteoclast formation and reduced bone resorption activity.
Link: https://www.sciencedirect.com/journal/journal-of-trace-elements-in-medicine-and-biology
Calomme et al., 2006 — Bone
Method: Long-term supplementation study in ovariectomised rats using bioavailable silicon.
Outcome: Partial prevention of femoral bone loss compared with controls.
Link: https://www.sciencedirect.com/journal/bone
Kim et al., 2009 — Biological Trace Element Research
Method: Silicon supplementation in calcium-deficient ovariectomised rat model.
Outcome: Improved bone mineral density and altered bone turnover markers.
Link: https://link.springer.com/journal/12011
Carlisle, 1980 — Journal of Nutrition
Method: Silicon-deficient animal model examining skeletal development.
Outcome: Impaired skull and bone matrix formation in silicon-deficient animals.
Link: https://academic.oup.com/jn
Jugdaohsingh, 2007 — Journal of Nutrition, Health & Aging
Method: Narrative review of silicon biology and skeletal health evidence.
Outcome: Summarised mechanistic, animal, and human data supporting silicon’s structural role in bone.
Link: https://link.springer.com/journal/12603
Frequently Asked Questions
Who is Silastra for?
Silastra is for anyone who wants to maintain strength, steadiness and day-to-day physical confidence as their body evolves.
It’s especially suited for:
Women in peri- and postmenopause, when shifts in collagen and bone-related processes become more noticeable
Adults over 40, who naturally produce less silicium as part of healthy ageing
Those who train, lift, walk, run or stay active, placing extra demand on joints and connective tissues
Silicium gradually drops in everyone — and it cannot be meaningfully restored through diet or typical supplementation alone.
What exactly does Silastra do?
Silastra helps your body rebuild its foundation from the inside out by restoring a mineral it gradually loses over time: bioavailable silicium.
This core nutrient supports:
Strong, resilient bone architecture
The body’s natural collagen-building processes
Joint and connective-tissue integrity
By targeting the body’s underlying structure, Silastra helps you feel more stable, less delicate and more assured in how you move.
A smart choice for anyone experiencing menopause, age-related changes or an active routine.
What's inside Silastra?
Mesoporosil® – A patented, highly absorbable silicium proven to support bone integrity and collagen pathways
Calcium – Key mineral for everyday skeletal strength
Vitamin D3 – Enhances the body’s use of calcium
Vitamin K2 – Helps direct minerals to where they’re structurally needed
How is Silastra different from other bone supplements?
Many bone formulas focus on excess calcium, a strategy that doesn’t fully tackle the body’s changing structural demands.
Silastra delivers highly absorbable silicium, the mineral involved in maintaining bone quality, collagen mechanics and joint support.
The result is a foundational approach — one that helps your body re-fortify its own structure, improving how supported and stable you feel day-to-day.
How is Silastra different from other collagen supplements?
Most collagen supplements give you collagen the body can’t use directly. Silastra doesn’t add collagen — it triggers the pathways behind it.
Once collagen is digested into amino acids, the body still needs silicium to reconstruct it into strong, resilient fibres.
Silastra delivers bioavailable silicium, which supports the body’s natural collagen production mechanisms.
That leads to stronger, better-organised collagen where it matters most — across joints, skin and connective tissues.
Can pregnancy or breastfeeding affect bone health?
The body uses a significant amount of the mother’s stored minerals during pregnancy and breastfeeding. Many women prioritise bone and connective-tissue support postnatally, and Silastra can be part of that routine.
Always speak to your doctor first before use.
What is the serving amount?
Take one softgel per day with water.
For optimal support, take consistently for 8–12 weeks.
How long will it take until I notice the results?
Structural changes take time. While improvements are not instant, many users report feeling more stable, aligned or flexible over several weeks to a few months.
Allow a minimum of 60 days for noticeable changes.
What if I forget a day?
Carry on as usual the next day. What matters most is steady, ongoing use.
I’m an athlete. Will this help with joint or bone stress?
Absolutely. Many active and high-impact athletes use Silastra to support their structural base.
It helps reinforce collagen and connective-tissue integrity during repeated stress.
At what age should I start taking Silastra?
Subtle structural changes begin earlier than most expect — usually late 30s to early 40s.
Starting Silastra around age 40, or sooner if you’re active or entering perimenopause, helps maintain long-term stability.
Early support means stronger structure later.